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ZYFLO CR® (zileuton) is Designed to Prevent the Formation of Leukotrienes

Watch how ZYFLO CR® works

This video explores the synthesis of leukotrienes and the mechanism of action of ZYFLO CR®.
The 5-lipoxygenase (5-LO) asthma pathway
Adapted from Steinke JW, et al. Curr Allergy Asthma Rep. 2007.
  • Leukotrienes contribute to the inflammatory process
  • ZYFLO CR® inhibits the synthesis of leukotrienes—including LTB4 and cysteinyl leukotrienes
  • ZYFLO CR® is the only FDA-approved leukotriene synthesis inhibitor
  • The efficacy of ZYFLO CR® versus LTRAs has not been established in comparative clinical trials

Please see Important Safety Information and Full Prescribing Information.

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Reference: 1. Steinke JW, Culp JA. Leukotriene synthesis inhibitors versus antagonists: the pros and cons. Curr Allergy Asthma Rep. 2007;7:126-133.